Opportunity Information: Apply for PAR 19 352
The NIH grant opportunity titled "Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional)" (Funding Opportunity Number PAR-19-352) supports research that tests interventions aimed at helping caregivers of adult cancer patients. The core idea is that cancer caregiving is not just a family issue but a major part of the patient care ecosystem, and caregiver strain, lack of training, or poor support can spill over into the patient experience, affecting symptoms, adherence, crisis events, and how often patients end up in high-cost settings like emergency departments or inpatient units. This FOA is looking for well-designed intervention studies that equip caregivers with practical care skills and emotional or behavioral coping tools so they can manage caregiving demands more effectively over time.
The interventions envisioned under this announcement focus on three linked outcome areas. First, projects should aim to optimize patient health care utilization, meaning the intervention should plausibly reduce avoidable or inefficient use of health services while supporting appropriate, timely care. That can include outcomes like fewer preventable emergency visits, fewer unplanned hospitalizations or readmissions, improved use of outpatient or supportive services, smoother transitions of care, or better coordination that prevents crises. Second, interventions are expected to improve caregiver well-being, which can include reducing stress, depression, anxiety, burden, sleep disruption, or social isolation, and improving caregiver confidence, preparedness, self-efficacy, and quality of life. Third, projects should aim to improve patient outcomes, both physical (for example, symptom control, functional status, treatment tolerance, adherence to care plans) and psychosocial (such as distress, mood, coping, communication, or overall quality of life). The FOA ties these together by treating caregiver support as a pathway to better outcomes for both the patient and the health system.
This is an R01 mechanism, which typically supports substantial, multi-year research projects that can rigorously test an intervention and generate strong evidence. The label "Clinical Trial Optional" indicates that applicants may propose studies that do or do not meet NIH's definition of a clinical trial; in practice, many caregiver intervention studies do involve randomization or other designs that qualify as clinical trials, but the announcement does not require it. What matters is that the application proposes intervention research with clear caregiver-focused content (such as care training and coping skills development) and a strong plan to measure the downstream effects on utilization, caregiver outcomes, and patient outcomes.
Eligibility is broad and includes many U.S.-based organization types: state, county, and local governments; special district governments; independent school districts; public and state-controlled universities; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it places firm limits on foreign involvement: non-U.S. entities and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed. In short, the work needs to be led and carried out within eligible U.S.-based organizational structures without foreign components.
Administratively, this is a discretionary grant opportunity from the National Institutes of Health. It sits within health and education-related funding activity categories and is associated with CFDA numbers 93.395 and 93.399. The FOA was created on 2019-08-29, and the listed original closing date is 2022-09-07. The source data does not specify an award ceiling, the expected number of awards, or other budget summary details, so applicants would typically look to the full FOA text and NIH policy for budget formatting expectations under the R01 mechanism.
Overall, PAR-19-352 is designed for investigators and organizations that want to test practical, scalable ways to strengthen the caregiver role in adult cancer care. Competitive projects will generally be those that make a clear case for why the caregiver intervention should change patient utilization patterns and patient outcomes, specify measurable endpoints in all three domains (utilization, caregiver well-being, and patient physical/psychosocial health), and use a rigorous design appropriate for an R01-level evaluation.Apply for PAR 19 352
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395, 93.399.
- This funding opportunity was created on 2019-08-29.
- Applicants must submit their applications by 2022-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR-19-352 (R01 Clinical Trial Optional)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional)" and the Funding Opportunity Number (FOA) is PAR-19-352.
What is the main purpose of PAR-19-352?
This FOA supports research that tests interventions for caregivers of adult cancer patients, based on the idea that caregiver strain, lack of training, and limited support can affect the patient experience and contribute to worse symptoms, poorer adherence, crisis events, and increased use of high-cost health care settings such as emergency departments and inpatient units.
Who is the intervention intended to help?
The interventions are aimed at caregivers of adult cancer patients. The FOA frames caregiver support as a pathway to improving outcomes for both caregivers and patients, while also influencing health care utilization.
What kinds of studies does this FOA want to fund?
The FOA is looking for well-designed intervention studies that equip caregivers with practical care skills and emotional or behavioral coping tools so they can manage caregiving demands more effectively over time. The research should also measure downstream effects on health care utilization, caregiver well-being, and patient outcomes.
What are the three main outcome areas projects are expected to address?
The FOA emphasizes three linked outcome areas: (1) optimizing patient health care utilization, (2) improving caregiver well-being, and (3) improving patient outcomes (physical and psychosocial). Applications are expected to specify measurable endpoints in all three domains.
What does "optimize patient health care utilization" mean in this FOA?
In this FOA, optimizing utilization means the intervention should plausibly reduce avoidable or inefficient use of health services while supporting appropriate and timely care. Examples mentioned include fewer preventable emergency department visits, fewer unplanned hospitalizations or readmissions, improved use of outpatient or supportive services, smoother transitions of care, and better coordination that helps prevent crises.
What caregiver outcomes are expected to improve?
The FOA highlights caregiver well-being outcomes such as reductions in stress, depression, anxiety, burden, sleep disruption, and social isolation, as well as improvements in caregiver confidence, preparedness, self-efficacy, and overall quality of life.
What patient outcomes are expected to improve?
The FOA anticipates improvements in both physical and psychosocial patient outcomes. Physical outcomes may include better symptom control, functional status, treatment tolerance, and adherence to care plans. Psychosocial outcomes may include improvements in distress, mood, coping, communication, and overall quality of life.
Why does NIH focus on caregivers in a cancer care grant?
The FOA treats caregiving as a core part of the patient care ecosystem. It suggests that when caregivers are strained or unsupported, it can spill over into the patient experience, affecting symptoms, adherence, crisis events, and patterns of health care utilization.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which typically supports substantial, multi-year research projects designed to rigorously test an intervention and generate strong evidence.
What does "Clinical Trial Optional" mean for PAR-19-352?
"Clinical Trial Optional" means applicants may propose studies that do or do not meet NIH's definition of a clinical trial. The FOA does not require a clinical trial design, though many caregiver intervention studies may involve randomization or other designs that qualify as clinical trials.
Is a randomized design required?
The information provided indicates that a randomized (or otherwise clinical-trial-qualifying) design is not required, because the FOA is labeled "Clinical Trial Optional." The key requirement is intervention research with clear caregiver-focused content and a strong plan to measure effects on utilization, caregiver outcomes, and patient outcomes.
What types of interventions fit this FOA?
Interventions envisioned under this FOA include those that provide caregivers with practical care training and skills, along with emotional or behavioral coping tools, with the intent of helping caregivers manage caregiving demands more effectively over time.
How should an application connect caregiver support to patient and system outcomes?
The FOA emphasizes that competitive projects will make a clear case for why the caregiver intervention should change patient utilization patterns and patient outcomes. Applications should connect caregiver training and coping support to measurable changes in utilization (for example, fewer avoidable emergency visits), caregiver well-being, and patient physical and psychosocial outcomes.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled universities; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses.
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; and regional organizations.
Are U.S. territories eligible?
Yes. The FOA notes eligibility includes U.S. territories or possessions.
Can foreign organizations apply?
No. Non-U.S. entities and foreign institutions are not eligible to apply under the limits described in the provided information.
Can a U.S. organization include a non-U.S. component?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed. The work needs to be led and carried out within eligible U.S.-based organizational structures without foreign components.
Which federal agency is offering this opportunity?
This is a discretionary grant opportunity from the National Institutes of Health (NIH).
What funding activity categories are associated with this opportunity?
The opportunity is described as sitting within health and education-related funding activity categories.
What CFDA numbers are associated with this FOA?
The FOA is associated with CFDA numbers 93.395 and 93.399.
When was this FOA created and what is the listed original closing date?
The FOA was created on 2019-08-29, and the listed original closing date is 2022-09-07.
Does the provided information include an award ceiling or expected number of awards?
No. The source information does not specify an award ceiling, the expected number of awards, or other budget summary details.
What budget details should applicants rely on if they are not provided here?
Based on the provided information, applicants would typically look to the full FOA text and NIH policy for budget formatting expectations under the R01 mechanism.
What would make a project competitive under PAR-19-352?
The FOA suggests that competitive projects will: (1) clearly justify why the caregiver intervention should change patient utilization patterns and patient outcomes, (2) specify measurable endpoints across utilization, caregiver well-being, and patient physical/psychosocial health, and (3) use a rigorous design appropriate for an R01-level evaluation.
Does the FOA focus on adult or pediatric cancer caregiving?
The FOA description provided specifies caregivers of adult cancer patients.
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