Opportunity Information: Apply for RFA CA 20 045
This funding opportunity is a limited competition NIH grant announcement (R01 mechanism; clinical trials not allowed) focused on renewing support for the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Hazards to Humans. The Monographs program is a long-running, highly visible international effort that critically reviews and synthesizes the published scientific literature to determine whether specific agents, exposures, or circumstances pose carcinogenic hazards to humans. The work is supported in part by the National Cancer Institute (NCI) and is positioned as a global public health resource: the resulting monograph volumes function as authoritative reference documents that help shape health policy decisions, guide cancer prevention strategies, and inform research priorities worldwide with the aim of reducing the global cancer burden.
The core activity supported by this FOA is the continuation (renewal) of the Monographs program itself, which centers on rigorous evaluation of existing evidence rather than generating new clinical trial data. In practice, this type of effort typically involves convening expert working groups, conducting systematic and transparent evidence reviews across human epidemiology, animal studies, and mechanistic data, and producing peer-referenced monograph volumes that summarize the state of the science and the basis for hazard classifications. The emphasis is on critical assessment of published findings and clear documentation of how conclusions are reached, so the final monographs can be relied upon by governments, regulators, researchers, clinicians, and other stakeholders concerned with cancer-causing exposures.
Eligibility is broad across many organization types, but the competition is described as limited, meaning it is restricted in who may realistically apply under NIH rules for this particular renewal. Eligible applicants listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments other than federally recognized, and U.S. territories or possessions.
International participation is allowed in a specific way. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are allowed. At the same time, non-domestic components of U.S. organizations are not eligible to apply, which is an important distinction for U.S.-based institutions that might otherwise propose an overseas branch or operational unit as the applicant component.
The sponsoring agency is the National Institutes of Health, with the program aligned to NCI support and the cancer-focused NIH assistance listings (CFDA numbers 93.393, 93.396, 93.399). The Funding Opportunity Number is RFA-CA-20-045, categorized as a discretionary grant opportunity in the education and health activity area. The original posting date is July 16, 2020, and the original closing date is December 16, 2020. No award ceiling or expected number of awards is provided in the source details you shared.Apply for RFA CA 20 045
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Limited Competition: International Agency for Research on Cancer (IARC) Monographs Program (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.396, 93.399.
- This funding opportunity was created on 2020-07-16.
- Applicants must submit their applications by 2020-12-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Funding Opportunity FAQs: RFA-CA-20-045 (IARC Monographs Renewal)
What is this funding opportunity about?
This is a limited competition NIH grant announcement using the R01 mechanism (clinical trials not allowed) focused on renewing support for the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Hazards to Humans.
What is the IARC Monographs program?
The IARC Monographs program is a long-running, highly visible international effort that critically reviews and synthesizes published scientific literature to determine whether specific agents, exposures, or circumstances pose carcinogenic hazards to humans.
Why is the Monographs program considered important?
The monograph volumes are positioned as a global public health resource and function as authoritative reference documents that help shape health policy decisions, guide cancer prevention strategies, and inform research priorities worldwide with the aim of reducing the global cancer burden.
What is the main activity supported by this FOA?
The core activity supported is continuation (renewal) of the Monographs program itself, emphasizing rigorous evaluation of existing evidence rather than generating new clinical trial data.
Are clinical trials allowed under this opportunity?
No. The announcement specifies an R01 mechanism with clinical trials not allowed.
Does this opportunity fund new data collection or new clinical trial research?
Based on the description provided, the emphasis is on evaluating and synthesizing existing published evidence rather than generating new clinical trial data.
What kinds of work are typically involved in producing the Monographs?
This type of effort typically involves convening expert working groups, conducting systematic and transparent evidence reviews across human epidemiology, animal studies, and mechanistic data, and producing peer-referenced monograph volumes that summarize the state of the science and the basis for hazard classifications.
What types of evidence are considered in the Monographs evaluations?
The work reviews evidence across human epidemiology, animal studies, and mechanistic data, and then documents how conclusions are reached for hazard classifications.
Who uses the resulting monograph volumes?
The final monographs are intended to be relied upon by governments, regulators, researchers, clinicians, and other stakeholders concerned with cancer-causing exposures.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), and the program is aligned with National Cancer Institute (NCI) support.
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA-CA-20-045.
What grant mechanism is used?
The opportunity uses the NIH R01 mechanism.
Is this a limited competition?
Yes. The opportunity is described as a limited competition, meaning it is restricted in who may realistically apply under NIH rules for this particular renewal.
Who is eligible to apply?
Eligibility is broad across many organization types. Eligible applicants listed include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations (other than federally recognized tribal governments)
- Public housing authorities / Indian housing authorities
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
Are any additional applicant categories explicitly highlighted as eligible?
Yes. The announcement also explicitly highlights additional eligible applicant categories such as:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISI)
- Hispanic-serving institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- Tribal governments other than federally recognized
- U.S. territories or possessions
Can non-U.S. (foreign) organizations apply?
Yes. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are eligible to apply.
Are foreign components allowed in applications?
Yes. Foreign components, as defined by the NIH Grants Policy Statement, are allowed.
Are non-domestic components of U.S. organizations eligible to apply?
No. The information provided states that non-domestic components of U.S. organizations are not eligible to apply, which is distinct from foreign organizations being eligible.
What is the purpose of the monograph volumes that result from this work?
The resulting monograph volumes serve as authoritative reference documents used to support health policy decisions, cancer prevention strategies, and global research priorities related to carcinogenic hazards.
What activity area is this opportunity categorized under?
It is categorized as a discretionary grant opportunity in the education and health activity area.
Which NIH assistance listings (CFDA numbers) are associated with this opportunity?
The program is aligned with cancer-focused NIH assistance listings (CFDA numbers 93.393, 93.396, 93.399).
What are the posting and closing dates provided?
The original posting date is July 16, 2020, and the original closing date is December 16, 2020.
Is an award ceiling provided?
No award ceiling is provided in the source details shared.
Is the expected number of awards provided?
No. The expected number of awards is not provided in the source details shared.
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